Figure 2.

T cells undergo distinct transcriptomic changes following SBRT/IL-12mRNA treatment

(A) Unsupervised clustering of intratumoral cells following scRNA-seq could identify four distinct cell subsets: Tumor/Stromal cells, Myeloid cells, B cells and T/NK cells. (B) Separating this clustering to treatment-specific UMAPs could identify significant transcriptomic changes to T cells and myeloid, in particular, following SBRT/IL-12mRNA treatment (see red and black highlighted regions). See materials and methods for further details.