Flowchart for Acute Calculous Cholecystitis management with a proposed algorithm based on updated evidence. The question marks indicate the “grey areas” (ACC, Acute Calculous Cholecystitis; ELC, Early Laparoscopic Cholecystectomy; EUS-GBD, UltraSound-guided GallBladder transmural Drainage; LAMS, Lumen Apposing Metal Stent; ETGBD, Endoscopic Transpapillary GallBladder Drainage; PGBD, Percutaneous Gallbladder Drainage; CBDS, Common Bile Duct Stones; EUS, Endoscopic UltraSound; MRCP, Magnetic Resonance CholangioPancreatography; IOC, Intraoperative Cholangiography; LUS, Laparoscopic UltraSound; ERCP, Endoscopic Retrograde Cholangiopancreatography).