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. Author manuscript; available in PMC: 2024 Oct 28.
Published in final edited form as: Chem Rev. 2023 Mar 7;123(14):8945–8987. doi: 10.1021/acs.chemrev.2c00814

Figure 16: Ellipsoidal phase boundary for a system with three associative macromolecules in a solvent.

Figure 16:

If three phases can coexist, as would be the case for the nucleolus 132 or nuclear speckle 131, then the tie simplex is a 2-simplex, which is a triangle. The concentrations of the macromolecules in the three coexisting phases will be determined by the direction cosines that define each side of the triangle.