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. Author manuscript; available in PMC: 2024 Oct 28.
Published in final edited form as: Chem Rev. 2023 Mar 7;123(14):8945–8987. doi: 10.1021/acs.chemrev.2c00814

Figure 9: Mapping of proteins onto different physical instantiations of associative macromolecules.

Figure 9:

(A) shows how intrinsically foldable domains (IFDs) may be mapped onto patchy colloids. (B) shows how intrinsically disordered regions (IDRs) may be mapped onto flexible, linear associative polymers. (C) shows how full-length proteins with IFDs and IDRs may be mapped onto specific combinations of patchy colloids and linear polymers. In all cases, black regions indicate spacers, and red and green regions indicate different types of stickers. Blue regions in (C) indicate oligomerization domains that behave as strong stickers.