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. 2024 Oct 15;5(10):101788. doi: 10.1016/j.xcrm.2024.101788

Figure 4.

Figure 4

TAC1 (substance P) is expressed in subpopulations of OPRM1-positive nociceptors

(A) Representative section of human DRG showing neurons expressing transcripts for TRPV1, the μ-opioid receptor (OPRM1), the chemo-sensitive receptor TRPA1, and substance P precursor (TAC1).

(B) Percentage of 1,316 neurons expressing each individual transcript.

(C) Percentage of neurons expressing the most common transcript combinations. Bar graphs in (B) and (C) show mean, SD, and individual values from four independent donors.

(D) Enlarged field shown in (A) for each individual transcript.

(E) Multi-channel microscopy images of a representative individual neuron of each population and the population’s cell size distribution. Scale bars, 25 μm. Lipofuscin is marked with an “L.”

(F) Expression intensity for TAC1 and TRPV1 in populations ii and v. The quad+ population ii shows significantly higher expression of TAC1 and TRPV1 and is polyresponsive to algesic mediators. Median and interquartile range indicated. p < 0.001, Mann-Whitney U test.