Figure 2.

Landscape of the gut mycobiome and key factors explaining the gut mycobiome inter-individual variation

(A) Taxonomic tree illustrating the genera with a prevalence greater than 10% in the CHNS-1 cohort (n = 10,695). Nodes (n = 54) within the inner to outer circles depict fungal taxa from phylum to genus levels, with genus-level nodes colored based on their respective phylum assignments. Reads that could not be confidently assigned to known taxa due to insufficient matching with reference sequences were labeled with the highest taxonomic rank that could be assigned, followed by “spp.”

(B) Distribution of fungal taxa that are present in at least 50% of samples at a minimum relative abundance of 0.1%.

(C) Variance in the mycobiome composition explained by phenotype categories was assessed through multivariate PERMANOVA analysis (n = 10,695). In this analysis, 54 genera with a prevalence greater than 10% were retained. The p value was determined through 999 permutations and subsequently adjusted for multiple testing. Notably, only the statistically significant results (FDR<0.05) are depicted in the figure.

See also Figures S1 and S2 and Tables S2 and S3.