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| group | N | agent | mg/kg |
|---|---|---|---|
| 1 | 10 | vehicle | |
| 2 | 10 | trastuzumab-deruxtecan (enhertu) | 2.5 |
| 3 | 10 | trastuzumab-deruxtecan (enhertu) | 1.25 |
| 4 | 10 | ADC 7 (AJICAP, APL-1092) | 10 |
| 5 | 10 | ADC 7 (AJICAP, APL-1092) | 5.0 |
| 6 | 10 | ADC 7 (AJICAP, APL-1092) | 2.5 |
| 7 | 10 | ADC 9 (interchain-break, APL-1092) | 2.5 |
| 8 | 10 | ADC 9 (interchain-break, APL-1092) | 1.25 |
