. 2024 Oct 3;67(20):18098–18123. doi: 10.1021/acs.jmedchem.4c01205

Table 2. Antiproliferation and Degradation Activities of Crizotinib-Based Degraders 7a–7i with Thalidomide as the E3 Binding Moiety^a.

IC₅₀ represents the concentration needed to inhibit cell growth by 50%. DC₅₀ is the concentration needed to reduce ROS1 or p-ROS1 protein by 50%. D_max is the maximal degradation of ROS1 or p-ROS1 in Ba/F3 cells.

Table 2. Antiproliferation and Degradation Activities of Crizotinib-Based Degraders 7a–7i with Thalidomide as the E3 Binding Moietya.

Table 2. Antiproliferation and Degradation Activities of Crizotinib-Based Degraders 7a–7i with Thalidomide as the E3 Binding Moiety^a.