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. 2024 Oct 16;67(20):18204–18220. doi: 10.1021/acs.jmedchem.4c01510

Figure 1.

Figure 1

Conversion of ANPs to their active metabolite via enzyme-catalyzed phosphorylation by nucleoside kinases (A) and representative structures for clinically relevant ANPs (B). NMPK, nucleoside monophosphate kinase; NDPK, nucleoside diphosphate kinase.