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. 2024 Oct 16;67(20):18204–18220. doi: 10.1021/acs.jmedchem.4c01510

Figure 6.

Figure 6

Mouse plasma and liver pharmacokinetic profiles of HTP-derived analogs of TXL. Male C57BL/6 mice (n = 3 per time point) were administered a single oral dose (10 mg/kg) of TFV prodrug using 90:10 olive oil:EtOH as a vehicle. Plasma, liver, and kidney levels of prodrug and TFV were quantified using LC–MS/MS. Liver (A), plasma (B), and kidney (C) concentrations of TFV prodrug and TFV metabolite are plotted together. Data represent the mean concentration at each time point ± SEM. The figures are generated with GraphPad Prism v9.

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