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Raw pairwise dynamic cross-correlation data for wild-type (3QL3, top) and mutant ecDHFR (3QL0, bottom). Pairwise correlations involving the residues Gly121, Gly51, and Ser77, respectively labeled red, blue, and green, were highlighted for their known millisecond conformational exchange as determined by CPMG and their respective involvement in active site loop conformation, substrate/product binding, and cofactor binding.
