Table 1.
Pharmacological profile comparison of X. tropicalis Tmem16a with published data from human TMEM16A (abc and acd isoforms).
| Compound | IC50 (n) X. tropicalis Tmem16a | Published human TMEM16A whole-cell patch clamp comparisons |
|---|---|---|
| Ani9 | 0.098 ± 0.009 µM (13) |
0.066 µM, human TMEM16Aacd61 52% inhibition at 0.05 µM, human TMEM16Aabc58 0.068 µM, human TMEM16Aabc65 |
| CaCCinhA01 | 12.91 ± 1.96 µM (9) |
7.84 µM, human TMEM16A62 7.57 µM, human TMEM16Aacd63 1.7 µM, human TMEM16Aacd60 |
| Benzbromarone | 3.30 ± 1.45 µM (10) |
3.05 µM, human TMEM16Aabc65 4.09 µM human TMEM16Aacd63 2.35 µM, human TMEM16Aacd64 |
| Niflumic acid | 85.12 ± 19.06 µM (4) |
8.34 µM, human TMEM16Aacd61 12.1 µM, human TMEM16Aacd60 8.54 µM human TMEM16Aacd63 |
| CFTR Inh-172 | > 30 µM (5) | |
| Idebenone | > 30 µM (4) | 54% and 90% inhibition by 10 µM and 30 µM respectively, human TMEM16A61 |
| MONNA | 11.89 ± 3.45 µM (6) | 13.60 µM human TMEM16Aacd63 |
| T16inh-A01 | > 30 µM (6) |
> 30 µM human TMEM16Aacd63 1.51 µM, human TMEM16Aacd60 |
| 9-AC | 145.9 ± 65.8 µM (5) | 57.7 µM, human TMEM16Aacd60 |