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Manhattan plots (A, C) and related quantile-quantile plots (B, D) showing sites of DNA methylation in whole blood associated with log-transformed childhood urinary fluoride (CUFsg) concentration in the CCAAPS among females (A, B) and males (C, D). Red line indicates epigenome-wide significance based on Bonferroni, (p < 6 × 10−8). Methylation of CpG sites that are significantly associated with log-transformed CUFsg are depicted by dots above the red line.
