Table 1.
Differentially expressed proteins associated with angiogenesis and fibrosis in the aqueous humor of patients with neovascular age-related macular degeneration (nAMD).
| Protein | Gene | nAMD/control (Log2 ratio) | p value | Gene ontology analysis | |
|---|---|---|---|---|---|
| 1 | Adipsin | CFD | 0.787 | 0.000 | Fibrosis |
| 2 | Alpha-1-antitrypsin | SERPINA1 | 0.590 | 0.000 | Pulmonary fibrosis |
| 3 | Aminopeptidase N | ANPEP | 0.613 | 0.026 | Angiogenesis |
| 4 | Apolipoprotein A-IV | APOA4 | 1.577 | 0.000 | Angiogenesis |
| 5 | Catalase | CAT | 1.557 | 0.000 | Fibrosis |
| 6 | CCN family member 3 | CCN3 | 0.980 | 0.019 | Angiogenesis |
| 7 | Collagen alpha-1(I) chain | COL1A1 | 0.740 | 0.005 | Pulmonary fibrosis |
| 8 | Desmoplakin | DSP | − 0.600 | 0.002 | Fibrosis |
| 9 | Endoplasmic reticulum aminopeptidase 1 | ERAP1 | 1.047 | 0.014 | Angiogenesis |
| 10 | Galectin-1 | LGALS1 | 1.353 | 0.001 | Pulmonary fibrosis |
| 11 | Galectin-3-binding protein | LGALS3BP | − 0.593 | 0.000 | Pulmonary fibrosis |
| 12 | Metalloproteinase inhibitor 1 | TIMP1 | 0.680 | 0.001 | Fibrosis |
| 13 | Platelet basic protein | PPBP | 1.300 | 0.003 | Angiogenesis |
| 14 | Vascular endothelial growth factor receptor 1 | FLT1 | 3.213 | 0.000 | Angiogenesis, pulmonary fibrosis |
| 15 | Vascular endothelial growth factor receptor 2 | KDR | 3.527 | 0.003 | Angiogenesis |