Fig. 5. The biosynthesis of aquastatin-related heteromeric depsides. (A) Phylogenetic analysis of TE domain sequences from selected fungal NR-PKSs. TE domain sequences from depside-forming NR-PKSs that utilise the SAT domain for depside bond formation are distantly related to NR-PKSs that employ the TE domain for this purpose. TE-releasing mechanisms are indicated. A more extensive phylogenetic analysis is presented in Fig. S119†. (B) The proposed biosynthetic pathway to the aquastatins.
