Bioassay results for compounds investigated in this studya.
| Compound | Minimum inhibitory concentration (MIC; μg mL−1) | IC50 (μM) | ||||
|---|---|---|---|---|---|---|
| B. subtilis | S. aureus | MRSA | S. cerevisiae | NS-1 | NFF | |
| Aquastatin A (1a) | 1.6 | 12.5 | 1.6 | >200 | >100 | >100 |
| Aquastatin B (1b) | 1.6 | >100 | >50 | >200 | >50 | >100 |
| Aquastatin D (1d) | 3.1 | 12.5 | 6.3 | 3.1 | >50 | >100 |
| Geministatin A (2a)* | 1.6 | 6.3 | 6.3 | >200 | >50 | >100 |
| Geministatin B (2b)* | 0.4 | 3.1 | 1.6 | >200 | >50 | >100 |
| Ariestatin A (3a) | 1.6 | 3.1 | 6.3 | >200 | >100 | >100 |
| Ariestatin B (3b) | 1.6 | 12.5 | 12.5 | >200 | >50 | >50 |
| Ariestatin C (3c) | >100 | >100 | >100 | >200 | 0.2 | >100 |
| Ariestatin D (3d) | 25 | >50 | >50 | 3.1 | >50 | >50 |
| Capricostatin A (4a) | 1.6 | 3.1 | 6.3 | >200 | >100 | >100 |
| Capricostatin B (4b) | 1.6 | 12.5 | 12.5 | >200 | 0.05 | >100 |
| Capricostatin D (4d) | 25 | >50 | >50 | 3.1 | >50 | >100 |
| Capricostatin F (4f) | 0.8 | 6.3 | 6.3 | >200 | 0.05 | >100 |
| Controls | 6.3 | 3.1 | >100 | 3.1 | 1.7 | 1.7 |
a
Controls: B. subtilis ATCC 6633 = tetracycline; S. aureus ATCC 25923 and MRSA ATCC 33592 = ampicillin; S. cerevisiae ATCC 9763 = blasticidin S HCl; NS-1 ATCC TIB-18 and NFF TCC PCS-201 = sparsomycin. * Results from Crombie et al.17