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. Author manuscript; available in PMC: 2024 Oct 28.
Published in final edited form as: Structure. 2019 Apr 18;27(6):1029–1033.e3. doi: 10.1016/j.str.2019.03.015

Figure 1. MORC3-CW Is a Target of NS1.

Figure 1.

(A) The amino-terminal sequence of H3 (trimethylated at lysine 4) and the C-terminal sequence of NS1 (trimethylated at lysine 229) are shown.

(B) Superimposed 1H,15N HSQC spectra of 15N-labeled MORC3-CW collected upon titration with the methylated and unmodified NS1 peptides. Spectra are color coded according to the protein-to-peptide molar ratio.

(C) The crystal structure of the MORC3-CW:NS1 complex. The CW domain is shown in a ribbon diagram (green), and NS1 is shown as sticks (yellow). The zinc (gray) atom is shown as a sphere.

(D) Electrostatic surface potential of the MORC3-CW domain colored blue and red for positive and negative charges, respectively. The bound NS1 peptide is yellow.

See also Figure S1.