Figure 6.
The overall structure of KmAgo-DMgDtR. (A) Domain architecture of KmAgo-DMgDtR with amino acid numbering. Domains and their unstructured residues are colored and labeled. (B, C) Cryo-EM density map (B) and ribbon diagrams (C) of KmAgo-DMgDtR, with domains colored as in (A). (D) Structural representation of KmAgo and other ternary complexes. (Left) TtAgogDtD (PDB: 4NCB); (middle left) CbAgogDtD (PDB: 6QZK); (middle right) KmAgo-DMgDtD; (right) TtAgogDtR (PDB: 3HK2). (E) Superposition of the guide DNA–target DNA and guide DNA–target RNA duplex depicted in (D) pairwise. The color schemes are designated by the corresponding labels.