Figure 2.

Timeline of some important discoveries, approvals, and advancements leading to long-acting HIV-1 therapeutics. Compounds are categorized as first-in-class (blue), newer-generation (green), and long-acting therapeutics (red) for treating and preventing infection. Chemical structure and delivery method(s) included for each antiviral on the right. Represented inhibitor classes are nucleoside reverse transcriptase inhibitor (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), integrase strand transfer inhibitors (INSTIs), and capsid-targeting antivirals. Pill and syringe icons designed by Freepik.