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. 2024 Oct 28;30:190. doi: 10.1186/s10020-024-00946-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Abnormal expression of MECOM in uterine corpus endometrial carcinoma and its mechanistic involvement in regulating the Hippo signaling pathway and affecting cell cycle and apoptosis. In endometrial cancer, decreased methylation levels of MECOM lead to increased expression. MECOM regulates cell cycle and apoptosis in endometrial cancer by affecting the phosphorylation levels of crucial TGF-beta signaling proteins, Smad. Additionally, changes in MECOM expression influence cell migration, which may subsequently affect tumor invasion and metastasis