Table 3.

Cox regression analysis for factors affecting the 3-year survival of intrahepatic cholangiocarcinoma in 141 patients enrolled in cohorts

Variable	No. of participants (n = 141)	Univariate analysis HR (95%CI)	P value	Multivariate analysis HR (95%CI)	P value
Tumor necrosis			0.01		0.03
0	50	1		1
0.5	6	1.31 (1.03, 1.62)		1.26 (1.13, 1.41)
1	85	1.93 (1.20, 3.12)		1.73 (1.06, 2.84)
Tumor metastasis			< 0.001		0.008
No	20	1		0.47 (0.27, 0.82)
Yes	121	2.53 (1.48, 4.32)		1
Child-Pugh			0.001		< 0.001
Group A	136	1		0.17 (0.07, 0.46)
Group B	5	4.49 (1.80, 11.22)		1
CD20			0.03		-
High	61	1
Low	80	1.65 (1.06, 2.58)
Paired adjacent tissues CD20			0.74		-
High	83	1
Low	58	1.48 (0.96, 2.26)
CD4			0.09		-
High	16	1
Low	125	2.04 (0.89, 4.69)
Paired adjacent tissues CD4			0.15		0.02
High	100	1		2.01 (1.13, 3.57)
Low	41	0.70 (0.43, 1.14)		1
CD8			0.16		-
High	73	1
Low	68	1.35 (0.88, 2.07)
Paired adjacent tissues CD8			0.01		< 0.001
High	84	1		0.4 (0.25, 0.67)
Low	57	1.75 (1.15, 2.68)		1
CK			0.01		0.04
High	112	1		0.58 (0.35, 0.96)
Low	29	1.86 (1.15, 3.02)		1
Paired adjacent tissues CK			0.16		-
High	104	1
Low	37	1.39 (0.88, 2.19)
CD68			0.30		-
High	113	1
Low	28	0.74 (0.42, 1.31)
Paired adjacent tissues CD68			0.35		-
High	130	1
Low	11	0.65 (0.26, 1.60)

0: No necrosis; 0.5: Partial necrosis; 1: Large or complete necrosis.