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. 2024 Oct 24;19:10725–10743. doi: 10.2147/IJN.S477159

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© 2024 Ramos-Zaldívar et al.

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Directional flow analysis by MRI of SPIONs and SPION-labeled exosomes through the cervical and meningeal lymphatic network. (a) Retrograde Directional Analysis: Brain images reveal the detection of nanoparticles in this region 30 minutes after injection into the deep cervical lymph node (n=3), particularly evident in the T2* map (yellow arrows). These two conditions were compared to control mice with no injected solutions (n=3). (b) Anterograde Directional Analysis: Neck images reveal the detection of nanoparticles in this region 30 minutes after injection into the cisterna magna (n=3), particularly evident in the T2* map (yellow arrows). These two conditions were compared to control mice with no injected solutions (n=3).