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. 2024 Oct 24;19:10725–10743. doi: 10.2147/IJN.S477159

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© 2024 Ramos-Zaldívar et al.

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Retrograde directional flow analysis by brain histology after in vivo nanoparticle administration into the deep cervical lymph node. (a) Combined Gold Enhancement and anti-LYVE-1 immunohistochemistry showed gold nanorods within meningeal lymphatic vessels (red arrows) and the brain parenchyma (yellow arrows), with no staining within cerebral arteries (n=3). (b) Meningeal lymphatic vessels stained with anti-LYVE-1 immunohistochemistry and colocalized with Chinese ink nanoparticles (red arrows). Chinese ink was also identified in the brain parenchyma (yellow arrows) (n=4).

Abbreviation: LYVE-1, lymphatic vessel endothelial hyaluronan receptor-1.