Fig. 1.

Sleep deficits in Shank3^∆C mice are dependent on time of day. Baseline time in state as percentage of total recording time (TRT). Wake, NREM sleep, and REM sleep during baseline light (white) and dark (gray) periods. N = 7/ sex/ genotype, mean value in gray bar. WT represented in black, Shank3^ΔC mice represented in red, filled represents males, unfilled represents females. # p-values < 0.05 across sex. *p-values < 0.05 across genotype for post hoc t-test with Benjamini–Hochberg correction A light period: Shank3^ΔC across sex p = 0.040 (Males: 36.5 ± 1.2%; Females: 42.6 ± 2.2%), females across genotype p = 0.010 (WT: 35.0 ± 2.3%; Mutant: 42.6 ± 2.2%). A dark period: males across genotype p = 0.020 (WT: 66.7 ± 2.0%; Mutant: 76.3 ± 1.5%), females across genotype p = 0.028 (WT: 72.1 ± 3.6%; Mutant: 63.4 ± 2.7%), Shank3^ΔC across sex p = 0.002 (Males: 76.3 ± 1.5%; Females: 63.4 ± 2.7%). B light period: females across genotype p = 0.009 (WT: 56.8 ± 2.1%; Mutant: 50.0 ± 1.8%). B dark period: males across genotype p = 0.018 (WT: 30.6 ± 1.9%; Mutant: 21.7 ± 1.4%), females across genotype p = 0.047 (WT: 25.4 ± 3.5%; Mutant: 32.6 ± 2.3%), Shank3^ΔC across sex p = 0.003 (Males: 21.7 ± 1.4%; Females: 32.6 ± 2.3%). C dark period: Shank3^ΔC across sex p = 0.001 (Males: 2.0 ± 0.2%; Females: 4.0 ± 0.5%), females across genotype p = 0.007 (WT: 2.5 ± 0.2%; Mutant: 4.0 ± 0.5%). Values in parentheses are mean ± SEM