Fig. 5.

Shank3^ΔC mice have an altered response to SD. Recovery time in state as percentage of total recording time (TRT) in wake, NREM sleep, and REM sleep. Light period white background, dark period gray background. WT represented in black, Shank3^ΔC mice represented in red, filled represents males, unfilled represents females (n = 7 WT males, 7 WT females, 6 Shank3^ΔC males, 7 Shank3^ΔC females). Mean value in gray bar. # p-values < 0.05 across sex. * p-values < 0.05 across genotype for post hoc t-test with Benjamini–Hochberg correction A light period: Shank3^ΔC across sex p = 2.011E-04 (Males: 29.7 ± 1.0%; Females: 43.7 ± 2.1%), females across genotype p = 0.1.474E-04 (WT: 29.9 ± 0.8%; Mutant: 43.7 ± 2.1%), dark period: males across genotype p = 0.002 (WT: 62.4 ± 2.5%; Mutant: 73.5 ± 2.5%). B light period: Shank3^ΔC across sex p = 2.610E-04 (Males: 60.3 ± 1.0%; Females: 48.2 ± 3.0%), females across genotype p = 1.053E-04 (WT: 60.7 ± 1.1%; Mutant: 48.2 ± 3.0%), dark period: males across genotype p = 0.001 (WT: 33.2 ± 2.0%; Mutant: 23.0 ± 2.1%). C light period: WT across sex p = 0.049 (Males: 10.6 ± 0.4%; Females: 9.4 ± 0.3%), Shank3^ΔC across sex p = 0.005 (Males: 10.1 ± 0.5%; Females: 8.1 ± 0.4%). Values in parentheses are mean ± SEM