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. 2024 Oct 24;17:7675–7685. doi: 10.2147/JIR.S486984

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© 2024 Gao et al.

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MK-4 promoted the expression of the Sirt3 and alleviated the acetylation of p53 induced by CLP. (A–F) Quantification of the relative expression of Sirt3, SLC7A11, p53 and acetylated lysine. (G–I) The acetylation of p53 and the ability of Sirt3 to bind to p53 were assessed by IP analysis. (J–L) The mRNA level of Sirt3, p53 and SLC7A11 in lung tissues of CLP-induced ALI. “*” indicates a significant difference between the corresponding groups (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).