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. Author manuscript; available in PMC: 2024 Oct 28.
Published in final edited form as: Vaccine. 2017 Mar 6;35(15):1964–1971. doi: 10.1016/j.vaccine.2017.01.053

Fig. 1.

Fig. 1.

HTS hits and derivatives induce the nuclear translocation of IRF3 and IRF3-dependent gene expression. (A) Structure of KIN1000 and its derivative KIN1148. (B) KIN1000 and KIN1148 induce dose-dependent nuclear translocation of IRF3 in PH5CH8 cells. (C) KIN1148 is more potent than KIN1000 as an activator of IRF3-dependent ISG54 and OASL expression by PH5CH8. (D) KIN1148 induces the production of IP-10 by PMA activated THP-1 cells. Experiments in were performed in duplicates for (B, C) and triplicates (C). Data are representative of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.