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. Author manuscript; available in PMC: 2024 Oct 28.
Published in final edited form as: Vaccine. 2017 Mar 6;35(15):1964–1971. doi: 10.1016/j.vaccine.2017.01.053

Fig. 2.

Fig. 2.

Prime-boost immunization with vaccine plus KIN1148 protects against lethal H1N1 challenge. Groups of 10 C57BL/6N mice were immunized twice, 21 days apart, with vaccine plus PBS, vaccine plus vehicle, or vaccine plus KIN1148. The mice were then challenged with 10× the LD50 of mouse-adapted influenza virus A/California/04/2009 21 days after boost. Mice were observed for 14 days after challenge (A) Survival. (B) Weight loss. Data are representative of two independent experiments. ***P < 0.001, ****P < 0.0001.