Reviewer name and names of any other individual's who aided in reviewer	Weiwen Wang
Do you understand and agree to our policy of having open and named reviews, and having your review included with the published manuscript. (If no, please inform the editor that you cannot review this manuscript.)	Yes
Is the language of sufficient quality?	Yes
Please add additional comments on language quality to clarify if needed
Is there a clear statement of need explaining what problems the software is designed to solve and who the target audience is?	Yes
Additional Comments
Is the source code available, and has an appropriate Open Source Initiative license <a href="https://opensource.org/licenses" target="_blank">(https://opensource.org/licenses)</a> been assigned to the code?	Yes
Additional Comments
As Open Source Software are there guidelines on how to contribute, report issues or seek support on the code?	Yes
Additional Comments
Is the code executable?	Unable to test
Additional Comments	This manuscript is about an online platform, and I am not sure how to test the code.
Is installation/deployment sufficiently outlined in the paper and documentation, and does it proceed as outlined?	Unable to test
Additional Comments	Same as above.
Is the documentation provided clear and user friendly?	Yes
Additional Comments
Is there enough clear information in the documentation to install, run and test this tool, including information on where to seek help if required?
Additional Comments
Is there a clearly-stated list of dependencies, and is the core functionality of the software documented to a satisfactory level?	Yes
Additional Comments
Have any claims of performance been sufficiently tested and compared to other commonly-used packages?	Not applicable
Additional Comments
Is test data available, either included with the submission or openly available via cited third party sources (e.g. accession numbers, data DOIs)?
Additional Comments
Are there (ideally real world) examples demonstrating use of the software?	Yes
Additional Comments
Is automated testing used or are there manual steps described so that the functionality of the software can be verified?
Additional Comments
Any Additional Overall Comments to the Author	With the increasing legalization of cannabis in many countries today, exploring this crop has become a hot topic of research. This manuscript by Mansueto et al. introduces a platform built on the Tripal framework, designed to facilitate multi-omics research in Cannabis sativa. The platform integrates genomic, transcriptomic, proteomic, and metabolomic data, providing researchers with a comprehensive resource for data analysis and sharing. Additionally, APIs have been developed, enabling rapid querying. This manuscript detailed information on how to customize Tripal modules and Chado schema for managing biological entities. Finally, this manuscript highlights the importance of standardization in data storage and analysis, proposing community-wide adoption of standardized nomenclature to ensure consistency and traceability of data. Overall, the platform is poised to become a valuable resource for cannabis research and to advance scientific progress in related fields. While this manuscript was engaging, particularly in the sections on Tripal "re-engineering" and controlled vocabulary, I do have several concerns. 1 Because my registration (using business email) has not been approved, I cannot test the functions requiring ICGRC registration. 2 The authors noted that the Cannabis Genome Browser has not been updated. Do the authors have a plan for updating ICGRC? If so, what is the proposed update frequency? 3 ICGRC currently includes only a few cannabis cultivars, especially when compared to other platforms like Kannapedia and CannabisGDB. Do the authors have plans to add additional cultivars, such as First Light and Jamaican Lions mentioned in this manuscript, in the near future? 4 When I tried to register using Gmail, an error popped up: ‘Domain is not allowed to register for this site’. Perhaps it would be clearer to instruct users to use a business email for registration directly. 5 There is a data submission function in ICGRC, but the exact workings of this feature remain unclear to me. If a user submits a cannabis genome to the ICGRC, whether this data will be visualized within specific modules like synteny search or genetic mapping tools on the platform.
Recommendation	Minor Revisions