Table 2.
Association between thyroxine replacement regimen and thyroid status in subjects with hypothyroidism
| Follow-Up TFTa | |||||
|---|---|---|---|---|---|
| Total | Under-replace | Euthyroid | Over-replace | P-value | |
| Index thyroxine Dose regimen | 0.193 | ||||
| Segmented dose (1/6) | 456 (7.9) | 135 (29.6) | 270 (59.2) | 51 (11.2) | |
| Segmented dose (2/5) | 1565 (27.2) | 461 (29.5) | 956 (61.1) | 148 (9.5) | |
| Alternate dose | 1112 (19.3) | 319 (28.7) | 696 (62.6) | 97 (8.7) | |
| Daily dose | 2616 (45.5) | 779 (29.8) | 1636 (62.5) | 201 (7.7) | |
| Index thyroxine Dose per kg BWb | 1.14 (0.43) | 1.15 (0.46) | 1.11 (0.41) | 1.33 (0.43) | < 0.001 |
| Index thyroxine Daily dose | < 0.001 | ||||
| High (≥ 125 μg) | 160 (2.8) | 61 (38.1) | 68 (42.5) | 31 (19.4) | |
| Low (≤ 75 μg) | 2954 (51.4) | 858 (29) | 1931 (65.4) | 165 (5.6) | |
| Medium (75–125 μg) | 2635 (45.8) | 775 (29.4) | 1559 (59.2) | 301 (11.4) | |
| Follow-up period | 0.178 | ||||
| Between 13 and 24 months | 606 (10.5) | 198 (32.7) | 356 (58.7) | 52 (8.6) | |
| Within one year (≤ 12 months) | 5143 (89.5) | 1496 (29.1) | 3202 (62.3) | 445 (8.7) | |
| Number of thyroxine prescriptionsc | 7.03 (2.57) | 7.45 (2.58) | 6.78 (2.51) | 7.38 (2.75) | < 0.001 |
| Number of thyroid function testsd | 4.58 (1.79) | 5.06 (1.88) | 4.27 (1.67) | 5.13 (1.85) | < 0.001 |
aThyroid function tests
bPer kilogram of body weight
cThyroxine prescription within 24 months from index thyroid test
dNumber of thyroid tests within 24 months from index thyroid test