Table 7.
GO pathway categories from protein profiles (key drivers) in each cell line derived EVs
| Cell type/Cell line | GO pathway categories | Proteins |
|---|---|---|
| Adenoma ZMTH3 | RNA processing | CPSF1 WDR43 EIF4A3 SNRPB DHX9 EFTUD2 SNRPD1 PRPF8 SF3B3 |
| mRNA processing | CPSF1 EIF4A3 SNRPB DHX9 EFTUD2 SNRPD1 PRPF8 SF3B3 | |
| mRNA metabolic process | CPSF1 EIF4A3 SNRPB DHX9 EFTUD2 SNRPD1 PRPF8 SF3B3 | |
| RNA splicing | EIF4A3 SNRPB DHX9 EFTUD2 SNRPD1 PRPF8 SF3B3 | |
| Simple + complex carcinoma | ECM organisation | MMP19 FBLN1 EXT1 TGFBI B4GALT1 ECM2 COL15A1 NTN4 LOXL3 APP PTX3 LOXL4 MMP2 PHLDB2 FBLN5 DAG1 COL6A1 QSOX1 OLFML2B LAMC1 LTBP3 PLOD3 ADAMTS7 COL5A2 VWA1 COL11A1 KAZALD1 |
| Cell adhesion | EZR PLXNB2 FBLN1 EXT1 TGFBI PTPRK PTK7 B4GALT1 ECM2 IGFBP7 NRP1 FAT4 LAMA4 BCAM TENM4 JAG1 ACTN4 P4HB PCDH1 ATRN NTN4 SPINK5 LOXL3 EDIL3 THBS1 CX3CL1 DSP PHLDB2 HAPLN3 PLXNB1 LAMC1 DLG1 NCAM1 RDX FN1 FBN1 ADAM10 MSN THBS3 EFNA1 SRPX2 DSC1 LAMA3 MXRA8 L1CAM FLNA CSF1 FSTL3 LAMB1 WNT5A CCN2 EPDR1 | |
| Cell motility | PLXNB2 PLG FBLN1 EXT1 PTPRK PTK7 B4GALT1 PLA2G7 MET NRP1 LAMA4 PRCP PAK1 JAG1 ATRN NTN4 APP THBS1 CX3CL1 SEMA5A PHLDB2 LGMN FSTL1 DAG1 APOH ENPEP ECM1 GPC1 PLXNB1 NRP2 LAMC1 ARPC5 LRRC15 CTSH GRN RDX FN1 IGFBP5 CXCL16 ADAM10 MSN EFNA1 SRPX2 SPARC SEMA7A LAMA3 MYO18A L1CAM FLNA CSF1 TGFBR3 CD151 LAMB1 WNT5A GNA12 | |
| Cell migration | PLXNB2 PLG EXT1 PTPRK PTK7 B4GALT1 PLA2G7 MET NRP1 LAMA4 PRCP PAK1 JAG1 ATRN NTN4 APP THBS1 CX3CL1 SEMA5A PHLDB2 LGMN FSTL1 DAG1 APOH ENPEP ECM1 GPC1 PLXNB1 NRP2 LAMC1 ARPC5 LRRC15 CTSH GRN RDX FN1 IGFBP5 CXCL16 ADAM10 MSN EFNA1 SRPX2 SPARC SEMA7A LAMA3 MYO18A L1CAM FLNA CSF1 TGFBR3 CD151 LAMB1 WNT5A GNA12 |