Table 3.
The effect of modifiable risk factors on progression to MCI and/or dementia
| Effect | CU | MCI | ||||||
|---|---|---|---|---|---|---|---|---|
| aHR (95% CI) | aHR (95% CI) | aHR (95% CI) | aHR (95% CI) | |||||
| Higher CAIDE score | A- | 1.6 (0.89; 2.93) | A + | 1.0 (0.49; 1.92) | A- | 3.1 (1.43; 6.53) | A + | 1.3 (0.98; 1.75) |
| T- | 1.1 (0.54; 2.40) | T + | 1.0 (0.55; 2.01) | T- | 1.6 (0.94; 2.83) | T + | 1.7 (1.20; 2.27) | |
| A-T- | 1.9 (0.80; 4.25) | A + T + | 0.9 (0.39; 2.15) | A-T- | 2.6 (1.06; 6.59) | A + T + | 1.6 (1.15; 2.22) | |
| Smoking | A- | n.e. | A + | n.e. | A- | 1.3 (0.39; 4.23) | A + | 1.6 (1.07; 2.34) |
| T- | n.e. | T + | n.e. | T- | 1.8 (0.89; 3.78) | T + | 1.5 (0.99; 2.31) | |
| A-T- | n.e. | A + T + | n.e. | A-T- | n.e. | A + T + | n.e. | |
| Depression | A- | 1.6 (0.81; 3.36) | A + | 1.0 (0.42; 2.60) | A- | 1.0 (0.48; 2.19) | A + | 1.2 (0.86; 1.57) |
| T- | 1.2 (0.44; 3.19) | T + | 1.1 (0.48; 2.45) | T- | 0.6 (0.30; 1.05) | T + | 1.5 (1.06; 2.02) | |
| A-T- | n.e. | A + T + | n.e. | A-T- | 0.6 (0.22; 1.49) | A + T + | 1.3 (0.94; 1.84) | |
Bold numbers indicate a significant increase
CU Cognitively Unimpaired, MCI Mild Cognitive Impairment, aHR adjusted Hazard Ratio, 95% CI 95% Confidence Interval, A- beta-amyloid negative, A + beta-amyloid positive, T- p-tau negative, T + p-tau positive, n.e. not estimated (due to small number of cases)