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. 2024 Oct 25;22:282. doi: 10.1186/s12957-024-03561-9

Table 4.

A review of the current literature on secretory carcinoma of salivary glands

Author Patients Gender Age Location Tumor size(cm) T1/T2/T3/T4/Tx N0/N1/N2/N3 M0/M1 Immunohistochemistry

Sun J et al.

(2021)

 23

Male 13(56.5%)

Female1(43.5%)

45

(10–69)

Parotid gland21(91.3%)

Submandibular gland 2(8.7%)

2.6

(0.8–4.8)

 6/14/3/0/0 18/1/4/0 21/2 S-100/MMG/CK7/GATA3 (+);Calponin/P63/DOG1 (-)
Serrano-Meneses GJ et al. (2024) 1 Male 11 Left maxillary soft tissue 5 T3N0M0

AE1-3/CK7/GATA3/S-100(+);

Actin/P63(-);

Ki-67 20%

Higuchi K et al.

(2014)

 7

Male 3(42.9%)

Female4(57.1%)

51.6

(39–68)

Parotid gland 5(71.4%)

Accessory paroid 1(14.3%)

Submandibular gland 1(14.3%)

1.8

(0.8–3.5)

 7/0/0/0/0 7/0/0/0 7/0

S-100/MMG/vimentin/MUC1(+);

Ki-67 7.8%(5-12.5%)

Min FH et al.

(2021)

 1 Male 32 Parotid gland 2 T1N0M0

S-100/MMG/CK5/6/7/8/Vim/SMA/p63(+);

DOG1/calponin(-);

Ki-67 2%

Salgado CM et al.

(2021)

 4

Male 2 (50%)

Female2(50%)

11

(7–14)

Parotid gland3(75%)

Submandibular gland1(25%)

1.5

(1.2–2.1)

 3/1/0/0/0 4/0/0/0 4/0

S-100/MMG/CK7/GATA3(+);

CK5/6/p53(-);

Ki-67 20–30%

Baněčková M et al.

(2023)

 215

Male123(57.2%)

Female8(40.5%)

Unknow 5(2.3%)

47.5

(7–94)

Parotid gland 159(74%)

Submandibular gland 14(6.5%)

Lip 12(5.6%)

Buccal mucosa 10 (4.7%)

Palate 10 (4.7%)

Oral cavity 5 (2.3)

Sinonasal tract 5 (2.3)

1.98

(4–70)

 129/48/6/7/25 97/10/10/98 120/6

S-100(+) 206/206

MMG(+) 195/197

DOG1(-) 127/147

NOR1(-) 73/73

p63(-) 152/178

Kim SH et al.

(2019)

 1 Male 40 Parotid gland 3.9 T3N0M0

EMA/Vimentin/S-100(+);

p63/CK5/6/C-KIT(-)

Wu B et al.

(2020)

 1 Male 72 Left nasal cavity 0.8 T1N0M0

S-100/MMG/GATA3(+);

p63/DOG1(+);

Ki-67 10%

Langah NA et al.

(2023)

 1 Male 42 Minor salivary glands 2.3 T1N2bMx

GATA3/MUC4(+);

AR(-)

Xu B et al.

(2017)

 1 Male 61 Maxillary sinus 4.2 T3N0M0 CK7/S-100/MMG/GCDFP-15(+)

Sun L et al.

(2019)

 1 Male 57 Parotid gland 1.6 T1N0M0

α-1-anti-trypsin/MMG/S-100(+);

AR/BRST-2/CK20/P63/SM(-);

Ki-67 5–10%

Boliere C et al.

(2019)

 1 Male 57 Minor salivary glands 1.0 T4N0M0

CK7/SM/P53/CK5/6/MMG/S-100(+);

DOG-1(-)

Martínez R et al.

(2019)

 1 Female 23 Minor salivary glands 2.0 T4N1M0

AE1/3/S-100/MMG/GATA3(+);

DOG1/p63(-);

Ki-67 20%

Cai Y et al.

(2019)

 5 Male 5(100%)

46

(34–60)

 Parotid gland

2.72

(2-3.5)

 1/3/1/0/0 5/0/0/0 4/1

S-100/MMG/Vimentin/CK(+);

p63(-);

Ki-67 10%

Gonzalez MF et al.

(2017)

 1 Male 18 Parotid gland 2.7 T2N0M0 MMG/S-100/SOX-10/MUC-1/4/p63(focal)/GCDFP-15(+)

Anderson JL et al.

(2019)

 55

Male 31(56.4%)

Female24(43.6%)

48.6

(12–82)

Parotid gland 42(76.4%)

Submandibular gland 3(5.5%)

Major salivary gland 10(18.2%)

 1.95 27/19/3/1/5 51/3/1 55/0 -

Ngouajio AL et al.

(2017)

 12

Male 6(50%)

Female6(50%)

15

(10–17)

Parotid gland 10(83%)

Submandibular gland 1(8.5%)

Lip 1(8.5%)

2.41

(1-3.8)

 3/6/1/0/2 11/1/0/0 12/0

S-100(+) 11(100%)

Vimentin(+) 4

CK19(+) 3

MMG(+) 2

Rooper LM et al.

(2018)

 1 Female 59 Submandibular gland 4.7 T3N2M0

S-100/MMG/p63(+);

DOG-1/SOX10(-)

Hsieh MS et al.

(2015)

 14

Male 8 (57%)

Female6 (43%)

32.5

(17–55)

 -

2.5

(1.2–4.5)

 5/6/3/0/0 11/2/1/0 -

S-100/MMG/Vimentin(+);

DOG1(93%)(-)

E.Boon et al.

(2018)

 31

Male17(55%)

Female14(45%)

49

(19–83)

Parotid gland 18(58%)

Submandibular gland 1(3%)

Minor salivary glands 12(39%)

 - 19/10/0/0/2 30/0/1/0 31/0 -

Bacem A et al.

(2017)

 279

Male 167(60%)

Female 112(40%)

 45.68

Parotid gland 189(68%)

Buccal mucosa 24(9%)

Submandibular gland 22(8%)

Lip 25 (9%)

Hard palate 12 (4%)

Soft palate 6(2%)

Base of the tongue 1 (0)

 1.8 - - - -

Din NU et al.

(2016)

 11

Male 7(63.6%)

Female 5(36.4%)

27.5

(9–60)

Parotid gland 7

Submandibular gland 3

Buccal vestibule 1

4.4

(2–10)

 - - -

S-100(+) 5/5

EMA(+) 4/4

CK7(+) 2/2