Table 2.
Oocyte aspiration cycle characteristics of the patients among the DOR group, high-risk DOR group and NOR group
| DOR | High-risk DOR | NOR | p1 | p2 | p3 | |
|---|---|---|---|---|---|---|
| Oocytes aspiration | ||||||
| No. of oocyte aspiration cycles, n | 1153 | 682 | 2649 | |||
| No. of retrieved oocytes, n, mean ± SD | 5.33±3.790 | 8.28±3.890 | 14.38±5.765 | <0.001 | <0.001 | <0.001 |
| No. of MII oocytes, n, mean ± SD | 4.85±3.297 | 7.23±3.559 | 12.47±5.359 | <0.001 | <0.001 | <0.001 |
| Mature oocyte rates, % | 88.5 | 87.4 | 86.5 | 0.146 | <0.001 | 0.189 |
| No. of cycles with no oocyte retrieved, n (%) | 39 (3.38) | 3 (0.44) | 5 (0.19) | <0.001 | <0.001 | 0.213 |
| No. of cycles with no MII oocyte retrieved, n (%) | 26 (2.33) | 3 (0.44) | 3 (0.11) | 0.003 | <0.001 | 0.104 |
| Insemination | ||||||
| Methods of Insemination | 1088 | 676 | 2641 | |||
| IVF, n (%) | 748 (68.8) | 435 (64.4) | 1658 (62.8) | 0.061 | <0.001 | 0.475 |
| ICSI, n (%) | 281 (25.8) | 165 (24.4) | 549 (20.8) | 0.536 | <0.001 | 0.046 |
| Half ICSI, n (%) | 59 (5.4) | 76 (11.2) | 434 (16.4) | <0.001 | <0.001 | 0.001 |
| Normal fertilization rates in MII oocyte cycles, %, mean ± SD | ||||||
| IVF (%) | 70.8±27.2 | 69.8±22.0 | 70.8±21.1 | 0.448 | 0.969 | 0.414 |
| ICSI (%) | 75.3±29.8 | 79.6±21.1 | 76.1±18.5 | 0.052 | 0.617 | 0.083 |
| Half ICSI (%) | 69.5±22.6 | 75.1±19.3 | 72.6±16.6 | 0.070 | 0.210 | 0.258 |
| Embryos culture | ||||||
| No. of cycles with viable embryos retrieved, n (%) | 973(84.39) | 654(95.89) | 2618(98.83) | <0.001 | <0.001 | <0.001 |
| No. of top-quality D3 embryos, n, mean ± SD | 1.96±1.731 | 2.66±2.036 | 4.43±3.009 | <0.001 | <0.001 | <0.001 |
| Top-quality D3 embryo rates, %, mean ± SD | 52.1±36.0 | 50.6±30.7 | 49.6±25.9 | 0.318 | 0.023 | 0.432 |
| No. of blastocyst culture cycles, n (%) | 572 (49.6) | 491 (72.0) | 2426 (91.6) | <0.001 | <0.001 | <0.001 |
| No. of viable blastocysts in blastocyst culture cycles, n, mean ± SD | 1.27±1.562 | 1.65±1.870 | 2.98±2.773 | 0.015 | <0.001 | <0.001 |
| Blastocyst rates per blastocyst culture cycles, %, mean ± SD | 38.4±38.4 | 37.0±34.4 | 40.0±28.9 | 0.665 | 0.271 | 0.117 |
| No. of viable D3 embryos, n, mean ± SD | 1.84±1.328 | 2.37±1.245 | 2.62±1.378 | <0.001 | <0.001 | <0.001 |
| No. of viable blastocysts in oocyte aspiration cycles, n, mean ± SD | 0.64±1.277 | 1.20±1.757 | 2.74±2.775 | <0.001 | <0.001 | <0.001 |
p1 DOR group vs. high-risk DOR group, p2 DOR group vs. NOR group, p3 High-risk DOR group vs. NOR group, IVF In-vitro fertilization, ICSI Intracytoplasmic sperm injection, Half ICSI Half number of MII oocytes fertilized by in-vitro fertilization and half number of MII oocytes fertilized by intracytoplasmic sperm injection