Table 2.

Association between anion gap (AG) and 28-day mortality risk in different models

	Model1 HR(95%CIs)	P	Model2 HR(95%CIs)	P	Model3 HR(95%CIs)	P	Model4 HR(95%CIs)	P
AG (mmol/L)	1.13 (1.09 ~ 1.18)	< 0.001	1.13 (1.09 ~ 1.18)	< 0.001	1.12 (1.07 ~ 1.17)	< 0.001	1.08 (1.04 ~ 1.13)	< 0.001
AG quartile group(mmol/L)
Q1(≤ 12)	1(Ref)		1(Ref)		1(Ref)		1(Ref)
Q2(13–14)	2.11 (0.92 ~ 4.86)	0.079	2.06 (0.89 ~ 4.73)	0.09	1.73 (0.73 ~ 4.11)	0.215	1.46 (0.86 ~ 2.48)	0.165
Q3(15–17)	2.65 (1.19 ~ 5.93)	0.017	2.46 (1.1 ~ 5.51)	0.029	2.25 (0.95 ~ 5.34)	0.066	1.75 (1.07 ~ 2.84)	0.025
Q4(≥ 18)	4.78 (2.24 ~ 10.2)	< 0.001	4.28 (2 ~ 9.17)	< 0.001	3.60 (1.60 ~ 8.07)	0.002	2.59 (1.69 ~ 3.99)	< 0.001
P for trend		< 0.001		< 0.001		0.001		0.004

Model 1: unadjusted

Model 2: Adjust for age, sex, race

Model 3: Adjust for age, sex, race, diabetes, sepsis, congestive heart failure, cerebrovascular disease, chronic pulmonary disease, rheumatic disease, acute kidney injury, CRRT

Model 4: Adjust for age, sex, race, diabetes, sepsis, congestive heart failure, cerebrovascular disease, chronic pulmonary disease, rheumatic disease, acute kidney injury, CRRT, LVEF, surgery, blood culture, SOFA score

Abbreviations: AG, anion gap; Q, quartile; HR, hazard ratio; CI, confidence interval; Ref, reference; LVEF, left ventricular ejection fraction