Table 2.
TCRpcDist‐3D versus TCRdist3: comparison of their predictive power for the 40 most represented peptides on VDJdb2022. Average of the area under receiver operating characteristic curves (AUC) and standard deviations are presented per approach and per peptide. The differences between the approaches are calculated and the peptide is highlighted in bold when the differences between the approaches are significant, with p‐values < 0.0001.
| Peptide | TCRpcDist‐3D | TCRdist3 | [AUC(TCRpcDist‐3D)]‐ [AUC(TCRdist3)] | ||
|---|---|---|---|---|---|
| AUC | SD | AUC | SD | ||
| AVFDRKSDAK | 56.78% | 0.08% | 54.63% | 0.08% | 2.2% |
| NLVPMVATV | 67.30% | 0.12% | 65.42% | 0.12% | 1.9% |
| IVTDFSVIK | 65.86% | 0.13% | 64.06% | 0.29% | 1.8% |
| SPRWYFYYL | 70.72% | 0.25% | 69.04% | 0.19% | 1.7% |
| CINGVCWTV | 72.91% | 0.20% | 71.34% | 0.35% | 1.6% |
| RLRAEAQVK | 68.26% | 0.15% | 67.24% | 0.27% | 1.0% |
| GPRLGVRAT | 75.88% | 0.23% | 75.02% | 0.24% | 0.9% |
| HPVTKYIM | 76.12% | 0.19% | 75.47% | 0.17% | 0.6% |
| RVAGDSGFAAY | 77.79% | 0.20% | 77.15% | 0.20% | 0.6% |
| FTSDYYQLY | 77.27% | 0.22% | 76.70% | 0.27% | 0.6% |
| NQKLIANQF | 74.95% | 0.16% | 74.38% | 0.12% | 0.6% |
| RPHERNGFTVL | 77.29% | 0.27% | 76.79% | 0.10% | 0.5% |
| QYIKWPWYI | 76.55% | 0.19% | 76.06% | 0.23% | 0.5% |
| ATDALMTGF | 72.47% | 0.30% | 72.02% | 0.22% | 0.4% |
| LTDEMIAQY | 71.79% | 0.16% | 71.37% | 0.15% | 0.4% |
| ALWEIQQVV | 77.26% | 0.13% | 76.88% | 0.20% | 0.4% |
| VYFLQSINF | 76.74% | 0.10% | 76.43% | 0.13% | 0.3% |
| DATYQRTRALVR | 73.47% | 0.31% | 73.24% | 0.18% | 0.2% |
| LLFGYPVYV | 76.75% | 0.13% | 76.52% | 0.13% | 0.2% |
| RTLNAWVKV | 76.68% | 0.12% | 76.51% | 0.12% | 0.2% |
| AYAQKIFKI | 77.06% | 0.11% | 76.99% | 0.08% | 0.1% |
| FLYALALLL | 80.27% | 0.05% | 80.26% | 0.07% | 0.0% |
| TPRVTGGGAM | 98.46% | 0.01% | 98.47% | 0.01% | 0.0% |
| KSKRTPMGF | 98.25% | 0.01% | 98.26% | 0.01% | 0.0% |
| LLYDANYFL | 78.17% | 0.13% | 78.19% | 0.14% | 0.0% |
| RPPIFIRRL | 77.68% | 0.16% | 77.92% | 0.14% | ‐0.2% |
| ALSKGVHFV | 77.09% | 0.12% | 77.34% | 0.13% | ‐0.3% |
| YSEHPTFTSQY | 77.26% | 0.21% | 77.51% | 0.09% | ‐0.3% |
| TTDPSFLGRY | 68.52% | 0.20% | 69.11% | 0.25% | ‐0.6% |
| ELAGIGILTV | 76.71% | 0.12% | 77.31% | 0.23% | ‐0.6% |
| RLPGVLPRA | 75.94% | 0.13% | 76.61% | 0.19% | ‐0.7% |
| GLCTLVAML | 70.41% | 0.31% | 71.31% | 0.42% | ‐0.9% |
| PTDNYITTY | 77.42% | 0.20% | 78.39% | 0.17% | ‐1.0% |
| RAKFKQLL | 65.34% | 0.17% | 66.32% | 0.11% | ‐1.0% |
| KLVALGINAV | 77.56% | 0.36% | 78.54% | 0.20% | ‐1.0% |
| NYNYLYRLF | 79.03% | 0.15% | 80.05% | 0.13% | ‐1.0% |
| RAQAPPPSW | 77.22% | 0.16% | 78.28% | 0.32% | ‐1.1% |
| YLQPRTFLL | 70.31% | 0.30% | 71.40% | 0.17% | ‐1.1% |
| GILGFVFTL | 74.07% | 0.59% | 75.71% | 0.55% | ‐1.6% |
| LLWNGPMAV | 72.44% | 0.32% | 76.52% | 0.21% | ‐4.1% |