Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2005 Jun 15;19(12):1438–1443. doi: 10.1101/gad.1299305

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2005, Cold Spring Harbor Laboratory Press

PMC Copyright notice

Figure 3. — Ink4a and Arf differentially contribute to histological abnormalities of the Bmi1^-/- cerebellum. (A) Morphological analysis of wild-type (left panels), Bmi1^-/- (middle left panels), Bmi1^-/-;Arf^-/- (middle right panels), and Bmi1^-/-;Ink4a/Arf^-/- (right panels) adult cerebellum. Haematoxylin and eosin (H&E, top and middle panels) staining shows rescue of overall cerebellar size and granular layer thickness in Bmi1^-/-;(Ink4a)Arf^-/- mice. (Bottom panels) Aberrant arborization of basket neurons (NF200 staining) is observed in all cerebella lacking Bmi1. Final magnification, 5× and 60×. (IGL) Internal granular layer; (ML) molecular layer. (B) IGL area measurements reveal similar significant rescues in Bmi1^-/-;Arf^-/- and Bmi1^-/-;Ink4a/Arf^-/- mice. (C) Ink4a/Arf loss induces a complete rescue of the number of Bmi1^-/- granule neurons, whereas Arf loss leads to a partial rescue (p < 0.01). (D) The partial rescue in number of Bmi1^-/- molecular layer neurons is significantly better in an Ink4a/Arf deficient background (p < 0.05) (HPF, high-power field; n = 4 mice).