TABLE 1.

Influence of virS and mymA disruption on the susceptibility of M. tuberculosis to antibiotics^a

Strain	MIC99 (μg/ml) at indicated pH of:
	Rifampin		Ciprofloxacin		Isoniazid		Ethambutol		Pyrazinamide
	7.0	5.0	7.0	5.0	7.0	5.0	7.0	5.0	5.0
M. tuberculosis Erdman	0.50	0.50	1.0	1.0	0.10	0.10	0.10	0.10	50
MtbΔvirS	0.125	0.0625	0.25	0.125	0.05	0.025	0.10	0.10	1
Mtbmym::hyg	0.125	0.0625	0.25	0.125	0.05	0.025	0.10	0.10	1
MtbΔvirS_virS	0.50	0.50	1.0	1.0	0.10	0.10	0.10	0.10	50

^aThe MIC₉₉ values were determined as described in Materials and Methods. Three independent experiments were carried out, and the same MIC₉₉ values were obtained.