TABLE 1.
Representative members of the eight secretion systems
| Secretion system | Substrate | Organism | Function |
|---|---|---|---|
| Sec dependent | |||
| AT | IgA1 protease | Neisseria gonorrhoeae | Protease of IgA1 |
| Tsh | Avian pathogenic Escherichia coli | Protease, adhesin | |
| Hap | Haemophilus influenzae | Adhesin, protease | |
| TPS | FHA | Bordetella pertussis | Hemagglutinin |
| ShlA | Serratia marcescens | Cytolysin | |
| HMW1A | Haemophilus influenzae | Adhesin | |
| CU | Components of P pili | Uropathogenic Escherichia coli | Adhesin |
| Components of type 1 pili | Uropathogenic Escherichia coli | Adhesin | |
| T2S | PulA | Klebsiella oxytoca | Starch-hydrolyzing lipoprotein |
| CT | Vibrio cholerae | Toxin | |
| LipA | Pseudomonas aeruginosa | Lipase | |
| ENP | CsgA | Escherichia coli | Curli component |
| Sec independent | |||
| T1S | HlyA | Enteropathogenic Escherichia coli | Hemolysin |
| PtrA | Erwinia chrysanthemi | Protease | |
| AprA | Pseudomonas aeruginosa | Alkaline protease | |
| T3S | Yops | Yersinia pestis | Multiple functions |
| InvA | Salmonella typhimurium | Invasin | |
| T4S | VirD2/transfer DNA | Agrobacterium tumefaciens | Tumorigenesis |
| PT | Bordetella pertussis | Toxin | |
| CagA | Helicobacter pylori | Activator of HGF/SF signaling pathway |