Figure 4.

Mammalian replication origins are enriched in peaks of enhanced flexibility. (A) Frequency of enhanced flexibility peaks within and outside initiation regions. Peaks of significantly enhanced flexibility (>M + 2.8 SD) were counted within (black histograms) and outside (grey histograms) initiation regions. Results are presented as the number of peaks per kilobase of sequence, for each locus, or for the combination of all loci. Results excluding (1) or including (2) the ori-β′ region are shown. (B) Frequency of doublets of peaks within and outside initiation regions. Doublets of peaks (peaks >M + 2.8 SD, separated by <2.5 kb) were counted and represented as before.