Table 2. Genetic variants used in the MR analysis.

Genetic instruments for OSA (Jiang et al) and their associations with VTE, PE, and DVT
				Exposure: OSA (Jiang et al)				Outcome: VTE			Outcome: PE			Outcome: DVT
	SNP	EA	OA	Beta	SE	p -Value	F-statistic	Beta	SE	p -Value	Beta	SE	p -Value	Beta	SE	p -Value
1	rs114417992	C	G	0.48798	0.10793	6.15E-06	20.4409	0.00702	0.04378	0.87253	−0.0542	0.06211	0.3832	−0.0052	0.06334	0.93511
2	rs115071002	T	C	−0.3775	0.0807	2.90E-06	21.8836	−0.0521	0.05045	0.30146	0.0359	0.07185	0.61729	−0.0633	0.07247	0.38241
3	rs117025138	C	G	0.42795	0.09571	7.78E-06	19.9915	−0.0149	0.05477	0.78611	0.0087	0.07809	0.91129	−0.0338	0.07836	0.66637
4	rs117474005	T	C	0.64176	0.14138	5.64E-06	20.6051	−0.0095	0.04108	0.81724	−0.0009	0.05862	0.98772	−0.0301	0.05891	0.60971
5	rs139183760	C	G	0.82973	0.16928	9.50E-07	24.0262	0.06514	0.07681	0.39643	0.04441	0.10929	0.68448	0.04761	0.11024	0.66585
6	rs148047757	A	G	0.47481	0.10699	9.08E-06	19.6952	−0.0522	0.0352	0.13769	−0.044	0.04999	0.37895	−0.0294	0.05078	0.562
7	rs150798389	C	A	0.7875	0.17391	5.95E-06	20.505	−0.2884	0.1435	0.04447	−0.2436	0.20053	0.22438	−0.1329	0.20679	0.52056
8	rs16850412	A	G	0.19514	0.04353	7.36E-06	20.0977	0.02674	0.01584	0.09145	0.04785	0.02253	0.03368	0.0173	0.02277	0.44739
9	rs1911999	C	T	−0.1312	0.02965	9.59E-06	19.5917	0.01759	0.01111	0.11349	0.0376	0.01577	0.01714	0.00223	0.01596	0.88889
10	rs2302012	A	G	0.12829	0.02871	7.88E-06	19.9669	−0.0104	0.01076	0.33549	−0.0272	0.0153	0.07541	0.00767	0.01545	0.61949
11	rs35963104	T	C	0.16572	0.03452	1.59E-06	23.0393	−0.0076	0.01354	0.57685	−0.02	0.01924	0.29896	−0.007	0.01942	0.71778
12	rs60445800	T	C	0.29191	0.06499	7.06E-06	20.1758	−0.0268	0.02361	0.25672	−0.0649	0.03349	0.05277	0.0112	0.03388	0.74095
13	rs9587442	T	C	0.44308	0.09584	3.78E-06	21.3735	−0.0385	0.03346	0.24969	−0.0101	0.04781	0.83322	0.00182	0.04783	0.96962
Genetic instruments for OSA (Campos et al) and their associations with VTE, PE, and DVT
				Exposure: OSA (Campos et al)				Outcome: VTE			Outcome: PE			Outcome: DVT
	SNP	EA	OA	Beta	SE	p -Value	F-statistic	Beta	SE	p -Value	Beta	SE	p -Value	Beta	SE	p -Value
1	rs10777826	T	C	−0.0319	0.00664	1.58E-06	23.0496	0.00684	0.01097	0.53296	0.01049	0.01557	0.50053	0.01763	0.01576	0.26318
2	rs10878269	T	C	0.03308	0.0069	1.61E-06	23.0112	−0.0208	0.01191	0.08097	−0.0262	0.01693	0.12108	−0.015	0.01711	0.37964
3	rs111909157	T	C	−0.1355	0.02658	3.40E-07	26.01	0.02664	0.04222	0.52808	0.03995	0.05999	0.5054	0.0364	0.06089	0.55
4	rs116114601	A	G	−0.0873	0.01969	9.20E-06	19.6692	−0.0401	0.04098	0.32779	−0.0676	0.05814	0.24516	−0.0182	0.05873	0.75679
5	rs11989172	C	G	−0.0378	0.00839	6.73E-06	20.268	−0.0217	0.01283	0.09	−0.039	0.01823	0.03222	0.01058	0.01842	0.56561
6	rs12265404	A	G	0.04931	0.01041	2.17E-06	22.4392	0.05233	0.0166	0.00162	0.05687	0.0233	0.01467	0.04278	0.02358	0.06956
7	rs12306339	A	C	−0.0488	0.01083	6.64E-06	20.295	−0.0051	0.01804	0.77914	−0.023	0.02561	0.37006	0.01462	0.02593	0.57292
8	rs13098300	T	C	0.03715	0.00712	1.84E-07	27.1962	0.00251	0.01202	0.83434	0.0101	0.01708	0.55432	5.55E-05	0.01727	0.99744
9	rs140548601	C	G	−0.1158	0.02428	1.85E-06	22.7529	0.05503	0.04711	0.24277	0.09206	0.06692	0.16895	0.04613	0.06762	0.49515
10	rs143417867	A	G	−0.3666	0.07088	2.30E-07	26.7599	−0.1487	0.2216	0.5021	0.15664	0.31582	0.61991	−0.0868	0.31594	0.78353
11	rs1942263	A	G	0.04569	0.01016	6.93E-06	20.214	−0.0156	0.01713	0.36361	−0.0136	0.02436	0.57584	−0.0318	0.02468	0.19751
12	rs2876633	A	T	−0.0355	0.00695	3.43E-07	25.9896	−0.0104	0.01158	0.36765	−0.0104	0.01645	0.52845	0.0032	0.01664	0.84772
13	rs35847366	A	G	0.0545	0.01172	3.31E-06	21.6318	−0.0365	0.01831	0.04596	−0.0383	0.02603	0.14125	−0.0511	0.02629	0.0517
14	rs36051007	T	C	0.03481	0.00716	1.14E-06	23.6682	−0.0037	0.01095	0.73452	−0.0145	0.01557	0.35199	0.00723	0.01573	0.64597
15	rs3774800	A	G	−0.0309	0.0069	7.79E-06	19.9898	0.00395	0.01151	0.73124	−0.0107	0.01634	0.51218	0.0093	0.01654	0.57396
16	rs4542364	A	G	0.03028	0.00673	6.69E-06	20.277	−0.0053	0.01084	0.6236	−0.0199	0.01541	0.19737	0.00163	0.01559	0.91663
17	rs4675933	T	C	−0.0329	0.00709	3.44E-06	21.5482	0.00822	0.01093	0.45187	0.00396	0.01554	0.79863	0.01593	0.01568	0.30957
18	rs533143	T	C	0.03237	0.00732	9.73E-06	19.5629	0.02892	0.01429	0.04304	0.02757	0.02031	0.1747	0.0111	0.02054	0.58881
19	rs60653979	A	G	0.03384	0.0068	6.43E-07	24.7805	0.01098	0.01083	0.31063	−0.0154	0.01539	0.31844	0.02887	0.01557	0.06364
20	rs62559379	C	G	0.0706	0.01455	1.22E-06	23.5419	−0.0163	0.02726	0.54934	−0.028	0.03871	0.46867	−0.0113	0.03915	0.77255
21	rs7106583	T	C	0.03868	0.00839	4.09E-06	21.2244	−0.0434	0.014	0.00194	−0.0205	0.02006	0.30655	−0.0414	0.0203	0.04114
22	rs72904209	T	C	−0.0446	0.00983	5.67E-06	20.5934	−0.0153	0.01617	0.34449	−0.0355	0.02292	0.1215	−0.0066	0.02327	0.77599
23	rs73141516	T	C	0.06496	0.01415	4.40E-06	21.0865	0.0084	0.02184	0.70062	−0.0241	0.03105	0.43797	0.03405	0.03133	0.27717
24	rs73164714	T	C	−0.0695	0.01285	6.43E-08	29.2248	−0.028	0.03721	0.45256	0.00562	0.05276	0.91513	−0.0139	0.05319	0.79352
25	rs7800775	A	G	0.03487	0.00785	8.98E-06	19.7136	0.00351	0.01357	0.79598	0.00758	0.01929	0.69414	−0.0166	0.01948	0.39528
26	rs794999	A	G	0.03421	0.00764	7.64E-06	20.0256	0.00108	0.01258	0.93171	0.0139	0.01786	0.43649	0.00374	0.01807	0.83582
27	rs9464135	A	G	−0.0309	0.00663	3.11E-06	21.7436	−0.0076	0.01055	0.47151	0.01164	0.015	0.43786	−0.0375	0.01516	0.01337
28	rs9567762	A	T	0.03635	0.00823	9.92E-06	19.5276	0.01223	0.01084	0.25934	0.00403	0.0154	0.7934	0.01552	0.01557	0.31884

Abbreviations: DVT, deep vein thrombosis; EA, effect allele; MR, Mendelian randomization; OA, other allele; OSA, obstructive sleep apnea; PE, pulmonary embolism; SE, standard error; SNP, single-nucleotide polymorphism; VTE, venous thromboembolism.

Note: F-statistic = (Beta/SE) ² , represents the strength of each instrumental variable