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. 2024 May 23;124(11):1061–1074. doi: 10.1055/a-2308-2290

Table 3. Genetic variants used in the reverse MR analysis.

Genetic instruments for VTE/PE/DVT and their associations with OSA (Jiang et al)
Exposure: VTE Outcome: OSA (Jiang et al)
SNP EA OA Beta SE p -Value F-statistic Beta SE p -Value
1 rs10896706 A G 0.0702142 0.0121006 6.53E-09 33.669456 −0.0597845 0.029345 0.0416207
2 rs113079063 T G 0.378107 0.0507769 9.59E-14 55.449428 0.0050364 0.0876134 0.954159
3 rs114026832 A C 0.773925 0.099915 9.50E-15 59.997944 0.0578773 0.180543 0.748533
4 rs114767153 T A −0.20888 0.0348173 1.98E-09 35.991798 −0.0712189 0.0909972 0.433833
5 rs116997538 T C 0.403288 0.0383066 6.42E-26 110.83665 −0.067735 0.123897 0.584581
6 rs12054563 G A −0.126677 0.0176431 6.97E-13 51.552027 0.0602695 0.0663601 0.363763
7 rs1560711 T C 0.122379 0.0141465 5.11E-18 74.836901 0.0310044 0.0321024 0.334145
8 rs174529 C T −0.0686342 0.0107211 1.54E-10 40.982878 −0.0053417 0.0276673 0.846904
9 rs188337046 T C 0.16048 0.0250424 1.47E-10 41.066712 0.178311 0.206621 0.388145
10 rs2066865 A G 0.186112 0.0112369 1.30E-61 274.31889 0.0083154 0.0313691 0.790945
11 rs2519785 G A −0.0702991 0.0118882 3.35E-09 34.967721 0.0074319 0.0297183 0.802526
12 rs3756011 A C 0.192712 0.0105525 1.65E-74 333.50841 −0.0026386 0.0272831 0.922956
13 rs57328376 G A 0.0697584 0.0109198 1.68E-10 40.809724 −0.0101806 0.0290533 0.726031
14 rs576123 T C −0.237396 0.0104973 3.09E-113 511.43633 0.00819 0.0287779 0.775956
15 rs5896 T C 0.109291 0.0125852 3.82E-18 75.413406 0.0614773 0.0388191 0.113265
16 rs6025 T C 0.873415 0.0298388 2.42E-188 856.79828 0.0502217 0.0899796 0.576745
17 rs6060308 A G 0.101587 0.0112359 1.55E-19 81.744876 0.0521936 0.0308737 0.0909227
18 rs60681578 C A −0.118392 0.0150029 2.99E-15 62.272211 0.0169103 0.0390773 0.665204
19 rs62350309 G A −0.173509 0.0181448 1.15E-21 91.440721 −0.071956 0.0634685 0.256909
20 rs628094 A G 0.0818781 0.0114389 8.19E-13 51.235029 0.0027028 0.0302168 0.928726
21 rs72708961 C T 0.0891913 0.0159445 2.22E-08 31.291269 −0.0765307 0.0367798 0.0374539
22 rs7772305 G A −0.0726964 0.0111586 7.28E-11 42.443031 0.0585778 0.0307164 0.0565137
23 rs78807356 T G 0.541094 0.0563616 7.96E-22 92.167713 0.101617 0.0796139 0.201825
Exposure: PE Outcome: OSA (Jiang et al)
SNP EA OA Beta SE p -Value F-statistic Beta SE p -Value
1 rs117210485 A G 0.150787 0.0228699 4.30E-11 43.470964 0.0214618 0.114177 0.8509
2 rs11758950 T C 0.203947 0.0367907 2.97E-08 30.729716 0.0418521 0.0821953 0.610627
3 rs143620474 A G 0.281243 0.0512263 4.01E-08 30.142375 0.546819 0.155226 0.0004271
4 rs1481808 C T −0.480929 0.0875759 3.98E-08 30.157318 −0.164933 0.105459 0.117828
5 rs1560711 T C 0.144704 0.0202073 8.01E-13 51.279584 0.0310044 0.0321024 0.334145
6 rs1894692 A G −0.547808 0.0457764 5.29E-33 143.21004 0.0002365 0.0951533 0.998017
7 rs2066865 A G 0.227484 0.0158067 5.85E-47 207.11869 0.0083154 0.0313691 0.790945
8 rs28584824 A C −0.155264 0.0279234 2.69E-08 30.917541 −0.0268756 0.0782108 0.731124
9 rs3756011 A C 0.234784 0.0149143 7.77E-56 247.81709 −0.0026386 0.0272831 0.922956
10 rs62350309 G A −0.202534 0.0260372 7.33E-15 60.507237 −0.071956 0.0634685 0.256909
11 rs635634 C T −0.239636 0.0177935 2.43E-41 181.37664 0.0064596 0.0347197 0.852404
12 rs665082 C G −0.175581 0.030484 8.42E-09 33.175015 −0.343267 0.216405 0.112688
13 rs77165492 C T 0.209269 0.0275462 3.03E-14 57.714695 −0.0445618 0.0457769 0.330327
14 rs78807356 T G 0.515784 0.0795096 8.75E-11 42.082022 0.101617 0.0796139 0.201825
Exposure: DVT Outcome: OSA (Jiang et al)
SNP EA OA Beta SE p -Value F-statistic Beta SE p -Value
1 rs113079063 T G 0.436284 0.0717563 1.20E-09 36.967365 0.0050364 0.0876134 0.954159
2 rs116997538 T C 0.466245 0.0534583 2.74E-18 76.067315 −0.067735 0.123897 0.584581
3 rs13377102 A T −0.233255 0.0255094 6.02E-20 83.610619 −0.0250186 0.0389518 0.520681
4 rs2066865 A G 0.184507 0.0161145 2.36E-30 131.09678 0.0083154 0.0313691 0.790945
5 rs2289252 T C 0.197972 0.015135 4.26E-39 171.09712 −0.0018411 0.0272571 0.946148
6 rs2519785 G A −0.0982467 0.0169973 7.46E-09 33.409968 0.0074319 0.0297183 0.802526
7 rs576123 T C −0.297682 0.014983 7.70E-88 394.73678 0.00819 0.0287779 0.775956
8 rs5896 T C 0.141024 0.017945 3.88E-15 61.75884 0.0614773 0.0388191 0.113265
9 rs6025 T C 1.10439 0.0393903 5.71E-173 786.07929 0.0502217 0.0899796 0.576745
10 rs6060237 G A 0.168453 0.0198214 1.92E-17 72.225216 0.0318432 0.0414073 0.441879
11 rs60681578 C A −0.137615 0.021627 1.98E-10 40.489181 0.0169103 0.0390773 0.665204
12 rs62350309 G A −0.162704 0.0259998 3.90E-10 39.161241 −0.071956 0.0634685 0.256909
13 rs666870 A G 0.0924832 0.0159069 6.10E-09 33.802949 0.0127968 0.0271558 0.637472
14 rs7308002 A G 0.0978174 0.01576 5.41E-10 38.522974 −0.0027934 0.0275746 0.919309
15 rs76151810 A C 0.153073 0.0273112 2.09E-08 31.413449 −0.0018493 0.0507256 0.970918
16 rs7772305 G A −0.100251 0.016057 4.28E-10 38.980608 0.0585778 0.0307164 0.0565137
17 rs78807356 T G 0.621447 0.0792414 4.42E-15 61.504078 0.101617 0.0796139 0.201825
18 rs9865118 T C 0.0863804 0.0151814 1.27E-08 32.374776 0.0363583 0.0268338 0.175436
Genetic instruments for VTE/PE/DVT and their associations with OSA (Campos et al)
Exposure: VTE Outcome: OSA (Campos et al)
SNP EA OA Beta SE p -Value F-statistic Beta SE p -Value
1 rs10896706 A G 0.0702142 0.0121006 6.53E-09 33.669456 0.0073376 0.0072794 0.3136
2 rs114767153 T A −0.20888 0.0348173 1.98E-09 35.991798 −0.0240477 0.0220217 0.2749
3 rs116997538 T C 0.403288 0.0383066 6.42E-26 110.83665 −0.0202903 0.0346251 0.558
4 rs12054563 G A −0.126677 0.0176431 6.97E-13 51.552027 −0.0164525 0.0159578 0.3025
5 rs1560711 T C 0.122379 0.0141465 5.11E-18 74.836901 −0.0033405 0.0090041 0.7104
6 rs174529 C T −0.0686342 0.0107211 1.54E-10 40.982878 −0.0016235 0.0068503 0.8124
7 rs2066865 A G 0.186112 0.0112369 1.30E-61 274.31889 −0.0033999 0.0077623 0.6612
8 rs3756011 A C 0.192712 0.0105525 1.65E-74 333.50841 0.000575 0.0067645 0.9326
9 rs57328376 G A 0.0697584 0.0109198 1.68E-10 40.809724 −0.0010062 0.0071873 0.8885
10 rs576123 T C −0.237396 0.0104973 3.09E-113 511.43633 0.0183551 0.0086786 0.03441
11 rs5896 T C 0.109291 0.0125852 3.82E-18 75.413406 0.020985 0.0096527 0.02974
12 rs6025 T C 0.873415 0.0298388 2.42E-188 856.79828 0.0380118 0.0218836 0.08241
13 rs6060308 A G 0.101587 0.0112359 1.55E-19 81.744876 −0.0009288 0.0074901 0.9013
14 rs60681578 C A −0.118392 0.0150029 2.99E-15 62.272211 0.0085067 0.0117172 0.4678
15 rs62350309 G A −0.173509 0.0181448 1.15E-21 91.440721 0.0075114 0.0152982 0.6233
16 rs628094 A G 0.0818781 0.0114389 8.19E-13 51.235029 −0.0022354 0.0074021 0.7627
17 rs72708961 C T 0.0891913 0.0159445 2.22E-08 31.291269 −0.0170636 0.0090957 0.06059
18 rs7772305 G A −0.0726964 0.0111586 7.28E-11 42.443031 0.016709 0.0086396 0.05311
19 rs80137017 T C −0.208902 0.0177996 8.30E-32 137.74147 0.0152022 0.0099426 0.1262
Exposure: PE Outcome: OSA (Campos et al)
SNP EA OA Beta SE p -Value F-statistic Beta SE p -Value
1 rs117210485 A G 0.150787 0.0228699 4.30E-11 43.470964 −0.0346523 0.0239146 0.1473
2 rs143620474 A G 0.281243 0.0512263 4.01E-08 30.142375 0.0124988 0.0892769 0.8889
3 rs1481808 C T −0.480929 0.0875759 3.98E-08 30.157318 −0.0281243 0.0269648 0.297
4 rs1560711 T C 0.144704 0.0202073 8.01E-13 51.279584 −0.0033405 0.0090041 0.7104
5 rs2066865 A G 0.227484 0.0158067 5.85E-47 207.11869 −0.0033999 0.0077623 0.6612
6 rs28584824 A C −0.155264 0.0279234 2.69E-08 30.917541 0.0324135 0.0191569 0.09056
7 rs3756011 A C 0.234784 0.0149143 7.77E-56 247.81709 0.000575 0.0067645 0.9326
8 rs62350309 G A −0.202534 0.0260372 7.33E-15 60.507237 0.0075114 0.0152982 0.6233
9 rs635634 C T −0.239636 0.0177935 2.43E-41 181.37664 0.0139975 0.0096935 0.1488
10 rs77165492 C T 0.209269 0.0275462 3.03E-14 57.714695 0.0013946 0.0114311 0.9026
11 rs80137017 T C −0.230014 0.02543 1.50E-19 81.811776 0.0152022 0.0099426 0.1262
Exposure: DVT Outcome: OSA (Campos et al)
SNP EA OA Beta SE p -Value F-statistic Beta SE p -Value
1 rs116997538 T C 0.466245 0.0534583 2.74E-18 76.067315 −0.0202903 0.0346251 0.558
2 rs13377102 A T −0.233255 0.0255094 6.02E-20 83.610619 0.0085579 0.0096591 0.3759
3 rs2066865 A G 0.184507 0.0161145 2.36E-30 131.09678 −0.0033999 0.0077623 0.6612
4 rs576123 T C −0.297682 0.014983 7.70E-88 394.73678 0.0183551 0.0086786 0.03441
5 rs5896 T C 0.141024 0.017945 3.88E-15 61.75884 0.020985 0.0096527 0.02974
6 rs6025 T C 1.10439 0.0393903 5.71E-173 786.07929 0.0380118 0.0218836 0.08241
7 rs6060237 G A 0.168453 0.0198214 1.92E-17 72.225216 0.0060526 0.0101724 0.5518
8 rs60681578 C A −0.137615 0.021627 1.98E-10 40.489181 0.0085067 0.0117172 0.4678
9 rs62350309 G A −0.162704 0.0259998 3.90E-10 39.161241 0.0075114 0.0152982 0.6233
10 rs666870 A G 0.0924832 0.0159069 6.10E-09 33.802949 0.0074616 0.0067221 0.2669
11 rs7308002 A G 0.0978174 0.01576 5.41E-10 38.522974 −0.0023644 0.0068533 0.7298
12 rs7772305 G A −0.100251 0.016057 4.28E-10 38.980608 0.016709 0.0086396 0.05311
13 rs9865118 T C 0.0863804 0.0151814 1.27E-08 32.374776 −0.0005648 0.0066442 0.9323

Abbreviations: DVT, deep vein thrombosis; EA, effect allele; MR, Mendelian randomization; OA, other allele; OSA, obstructive sleep apnea; PE, pulmonary embolism; SE, standard error; SNP, single-nucleotide polymorphism; VTE, venous thromboembolism.

Note: F-statistic = (Beta/SE) 2 , represents the strength of each instrumental variable.