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. 2024 Oct 15;15:1468229. doi: 10.3389/fimmu.2024.1468229

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Copyright © 2024 Santos, Rezende, Piraine, Oliveira, Ferreira, Carvalho, Calado, Pellegrini and Almeida

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sensitive breast cancer cells uptake resistant extracellular vesicles (EVs) and show increased cell viability. (A) Sensitive MCF-7 cells (Bright field) internalizing the EVs (Vybrant dil) after 24 h of exposure. (B) Sensitive MDA-MB-231 cells (Bright field) internalizing the EVs (Vybrant dil) after 24 h of exposure. TAM-R: tamoxifen-resistant; DOX-R: doxorubicin-resistant; ns: non-significant. A resazurin reduction assay evaluated the cell viability of sensitive (C) MCF-7 and (D) MDA-MB-231 cells exposed to resistant EVs. (E) Spheroids of sensitive MCF-7 cells were previously exposed to sensitive, TAM- and DOX-resistant EVs for 24 h and treated with TAM or DOX for 72h. The asterisks indicate a significant difference (p < 0.05) between tamoxifen or doxorubicin treatments when compared to no treatment (unpaired t-test).