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. 2024 Oct 15;15:1468229. doi: 10.3389/fimmu.2024.1468229

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Copyright © 2024 Santos, Rezende, Piraine, Oliveira, Ferreira, Carvalho, Calado, Pellegrini and Almeida

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptome-wide analysis showing the differential expression in sensitive breast cancer cell lines exposed to resistant extracellular vesicles (EVs) for 24 hours. (A) Histogram of the total number of differentially expressed genes (DEGs) in MCF-7 and MDA-MB-231. Distribution of gene ontology (GO) slim terms associated with MCF-7 transcripts after tamoxifen-resistant EVs (TAM-R EVs) exposure (B) and doxorubicin-resistant EVs (DOX-R EVs) exposure (C). For MDA-MB-231, the distributions of GO-slim enriched terms after TAM-R and DOX-R EV exposure are shown in (D, E), respectively. (F) Heatmap showing each condition’s top 10 up- and downregulated genes based on their log2 fold change.