Table 1.

The differences between apoptosis and ferroptosis.

	Morphological features	Key biochemical pathway components
Apoptosis	Nuclear rupture, plasma membrane blistering, cell shrinkage, apoptotic body formation and phagocytosis of neighboring cells.	Proapoptotic B-cell lymphoma-2 (BCL-2) family members, caspase activation, cleavage of hundreds of caspase substrates (e. g. intracranial atherosclerotic disease (ICAD), Poly ADP-ribose polymerase (PARP)), phosphatidylserine exposure, Mitochondrial Membrane Potential (△ψm) dissipation, Manganese-Based Tumor Immunotherapy (MOMP) and ROS production.
Ferroptosis	Smaller mitochondria, reduced condition, increased membrane density, mitochondrial membrane rupture, but normal nucleus.	Iron accumulation, cysteine deprivation, and/or glutathione peroxidase inactivation eventually lead to lipid peroxidation.