Table 3.

HR with 95% CI from Cox Proportional hazards models in 6837 patients diagnosed with esophageal cancer for the outcome death by any cause

		All patients
		Multivariate
		HR	(95% CI)	p
MDT
	No	1.00	(Ref.)	—
	Yes	0.72	(0.66–0.78)	<0.001
Sex
	Female	1.00	(Ref.)	—
	Male	1.11	(1.03–1.19)	0.006
Age at diagnosis (years)
	<50	1.00	(Ref.)	—
	50–59	1.21	(1.01–1.46)	0.046
	60–69	1.30	(1.09–1.55)	0.003
	70–79	1.54	(1.29–1.84)	<0.001
	80–89	1.69	(1.40–2.05)	<0.001
	90 and above	3.11	(2.34–4.14)	<0.001
Marital status
	Unmarried	1.00	(Ref.)	—
	Married	0.93	(0.87–0.99)	0.025
Education level
	Low (<9 years)	1.00	(Ref.)	—
	Intermediate (10 – 12 years)	0.92	(0.86–0.99)	0.025
	High (>12 years)	0.86	(0.78–0.94)	0.001
CCI score
	0–1	1.00	(Ref.)	—
	2	0.94	(0.86–1.04)	0.242
	3 or above	1.13	(1.06–1.21)	<0.001
Histopathology
	Adenocarcinoma	1.00	(Ref.)	—
	Squamous	1.24	(1.15–1.33)	<0.001
Clinical disease stage
	Stage 0	1.00	(Ref.)	—
	Stage I	0.99	(0.64–1.54)	0.968
	Stage II	1.55	(1.04–2.32)	0.033
	Stage III	2.17	(1.46–3.23)	0.004
	Stage IVa	2.47	(1.65–3.72)	<0.001
	Stage IVb	3.34	(2.24–4.99)	<0.001
Year of diagnosis
	2005–2009	1.00	(Ref.)	—
	2010–2013	1.09	(1.01–1.18)	0.033
	2014–2018	0.99	(0.91–1.08)	0.887
Treatment allocation
	Curative treatment	1.00	(Ref.)	—
	Palliation	2.47	(2.25–2.70)	<0.001

Clinical T-, N- and M-stage calculated according to the 8th edition of the AJCC/UICC TNM classification system

Association with improved outcome

Association with poorer outcome