Table 3.
Cancers, metabolic diseases and cardiovascular diseases that are linked with selective autophagy.
| Diseases | Forms of selective autophagy | Key protein /pathway | References |
|---|---|---|---|
| Breast cancer | Mitophagy, ER-phagy | DRP1, CALCOO1 | [151] |
| CRC | Mitophagy, ER-phagy | Akt/mTOR pathway, TEX264, FAM134B, CALCOO1 | [152], [157] |
| Cervical cancer | Mitophagy, ER-phagy | Parkin, SEC62 | [36], [153]. |
| Ovarian cancer | Mitophagy | CRL4 | [155] |
| AML | Mitophagy | OPTN | [156]. |
| Prostate cancer | ER-phagy | SEC62 | [262] |
| NSCLC | ER-phagy | SEC62 | [36]. |
| ESCC | ER-phagy | FAM134B | [158] |
| HCC | ER-phagy | FAM134B | [159] |
| Pancreatic cancer | ER-phagy | FAM134B | [160] |
| Gastric cancer | Xenophagy | LC3 | [177] |
| Metabolic syndrome | Lipophagy | FGF21 | [184] |
| Obesity cardiomyopathy | Mitophagy, Lipophagy | DRP1, Parkin, FUNDC1 | [181], [188], [263] |
| Diabetes | ER-phagy, Lipophagy | PTP1B | [182] |
| NAFLD | Lipophagy | FGF21 | [184] |