Table 5.
Small-molecule inhibitors of selective autophagy.
| Names | Chemical structure | Selective autophagy types of action | Targets | Indications | Ref. |
|---|---|---|---|---|---|
| Mdivi-1 |  |
Mitophagy | Drp1 | Cardiovascular diseases, neurodegenerative diseases such as AD and PD. | [230], [265] |
| S89 |  |
Mitophagy | MFN1 | Cardiovascular diseases | [266] |
| Oroxylin A |  |
Mitophagy | PINK9 | HCC | [231] |
| Fluorizoline |  |
Mitophagy | PHB1, PHB2 | Breast cancer, lung cancer | [232] |
| Roflumilast |  |
Mitophagy | Drp1, PINK1 | Emphysema | [234] |
| Compound 6 |  |
Mitophagy | Parkin | Colorectal cancer | [233] |
| Vitexin |  |
ER-phagy | FAM134B | Breast cancer | [235] |
| Trifluoperazine |  |
ER-phagy | SEC62 | Prostate cancer | [236] |
| STF-083010 |  |
ER-phagy | IRE1 | Acute renal failure | [237] |
| 4-PBA |  |
ER-phagy | HDAC | Myocardial ischemia–reperfusion injury, ophthalmic diseases such as glaucoma |
[238] |