TABLE 5.
In vitro synergism between tacrolimus and ketoconazole
| Species | Strain no. | KTZ
|
Tacrolimus
|
FIX | ||||
|---|---|---|---|---|---|---|---|---|
| MIC (μg/mL)
|
FIC index | MIC (μg/mL)
|
FIC index | |||||
| KTZ alone | KTZ combined with tacrolimus | Tacrolimus alone | Tacrolimus combined with KTZ | |||||
| M. globosa | 5 | 0.125 | 0.03 | 0.25 | >32 | 8 | 0.125 | 0.375 |
| 7 | 0.125 | 0.03 | 0.25 | >32 | 8 | 0.125 | 0.375 | |
| 9 | 0.125 | 0.03 | 0.25 | >32 | 4 | 0.125 | 0.375 | |
| M. restricta | 6 | 0.125 | 0.03 | 0.25 | >32 | 8 | 0.125 | 0.375 |
| M. sympodialis | 24 | 0.125 | 0.03 | 0.25 | 32 | 4 | 0.125 | 0.375 |
| M. furfur | 7 | 0.125 | 0.03 | 0.25 | 32 | 4 | 0.125 | 0.375 |