Table 1.

Multilevel model analysis of prenatal tobacco smoke exposure and off-target RAG-mediated deletions in childhood ALL patients.

Full RSS motif at deletion breakpoints*	Univariable model**			Multivariable model**
	Tobacco exposure, OR (95% CI)	Age-at-diagnosis, OR (95% CI)	Hispanic/Latino ethnicity***, OR (95% CI)	Tobacco exposure, adjusting for age-at-diagnosis, OR (95% CI)	Tobacco exposure, adjusting for age-at-diagnosis and ethnicity, OR (95% CI)
One or both breakpoints	2.44 (1.13, 5.38)	1.12 (1.02, 1.24)	1.22 (0.56, 2.75)	1.95 (0.88, 4.41)	2.17 (0.95, 5.13)
Both breakpoints	4.70 (1.34, 29.75)	1.06 (0.96, 1.23)	1.47 (0.61, 3.90)	4.41 (1.16, 28.96)	5.81 (1.42, 39.84)

*FIMO was used to identify a full RSS motif (heptamer and nonamer motif plus 12- or 23-nucleotide spacer) within 50 bp of one or both deletion breakpoints.

**Multilevel logistic regression models were used to estimate the association between prenatal tobacco exposure (18 high exposure vs. 17 low exposure patients) and having a full RSS motif at one or both breakpoints of non-Ig-TCR (i.e., “off-target”) deletions (n = 311).

***Analyses were limited to self-reported Hispanic/Latino vs. non-Hispanic due to sample size.